入江 厚
I. 略歴
II. 専門分野、所属学会、受賞など
III. 発表論文
氏名：入江 厚（いりえ あつし）
所属：熊本大学大学院生命科学研究部 免疫識別学分野 講師
住所：〒860-8556 熊本市中央区本荘１丁目１番１号
TEL：096-373-5313
FAX：096-373-5314
専門分野：免疫生物化学 T細胞活性化分子の探索、質量分析法による免疫細胞のブロテオーム解析
所属学会：日本免疫学会
Fukunaga T, Soejima H, Irie A, Sugamura K, Oe Y, Tanaka T, Kojima S, Sakamoto T, Yoshimura M, Nishimura Y, Ogawa H. Expression of interferon-g and interleukin-4 production in CD4(+) T cells in patients with chronic heart failure. Heart Vessels. 22: 178-83, 2007.
Irie, A., Harada, K., Tsukamoto, H., Kim, J-R., Araki, N., and Nishimura, Y. Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR-stimulation depending on its activity in Jurkat cells. Int. Immunol. 18: 1737-1747, 2006.
Tsukamoto, H., Irie, A., kim, J-R., Chen, Y-Z., Takeshita, K., and Nishimura, Y. TCR ligand avidity determines the mode of B-Raf/Raf-1/ERK activation leading to the activation of human CD4+ T cell clone. Eur. J. Immunol. 36: 1926-1937, 2006.
Kim, J-R., Irie, A., Tsukamoto, H., and Nishimura, Y. A role of kinase inactive ZAP-70 in altered peptide ligand stimulated T cell activation. Biochem. Biophys.Res.Comm. (IF=3.0) 341:19-27, 2006.
Soejima H, Irie A, Fukunaga T, Sugamura K, Kojima S, Sakamoto T, Yoshimura M, Kishikawa H, Nishimura Y, Ogawa H. Elevated plasma osteopontin levels were associated with osteopontin expression of CD4(+) T cells in patients with unstable angina. Circ.J. 70:851-856, 2006.
A, Irie, Y-Z, Chen, H, Tsukamoto, T, Jotsuka, M, Masuda, and Y, Nishimura. Unique T-cell proliferation associated with PKCμ activation and impaired Zap-70 phosphorylation in recognition of overexpressed HLA-DR/partially agonistic peptide complexes. Eur.J.Immunol. 33:1497-1507, 2003
H, Soejima, A, Irie, S, Miyamoto, I, Kajiwara, S, Kojima, J, Hokamaki, T, Sakamoto, T, Tanaka, M, Yoshimura, Y, Nishimura, and H, Ogawa. The preference to a Th1-type response in patients with coronary spastic angina. Circulation 170: 2196-2200, 2003
T. Kamata, K.K. Tieu, A, Irie, T.A. Springer, and Y. Takada. Amino acid residues in the aIIb subunit that are critical for ligand binding to integrin aIIbb3 are clustered in the b-propeller model. J.Biol.Chem. 276:44275-44283, 2001
M. Minohara, H. Ochi, S. Matsushita, A. Irie, Y. Nishimura and J. Kira. Differences between T cell reactivities to major myelin protein-derived peptides in opticospinal and conventional forms of multiple sclerosis and healthy controls. Tissue Antigens 57:447-456, 2001
J.M.G. Higgins, M. Cernadas, K. Tan, A. Irie, J. Wang, Y. Takada and M.B. Brenner. The role of a and b chains in ligand recognition by b7 Integrins. J.Biol.Chem. 275:25652-25664, 2000
入江 厚、他１名 抗原提示細胞とＴ細胞のインターフェースにおける抗原認識の分子機構 臨床免疫 34:197-203, 2000
入江 厚、他１名 免疫遺伝学と遺伝病 病理と臨床 18:841-852, 2000
入江 厚、他１名 抗原提示細胞とＴ細胞のインターフェースにおける抗原認識の分子機構 Annual Review 免疫 2001（矢田、奥村、佐藤 編） 中外医学社、p84-93, 2000（分担）
C. Yun, S. Senju, H. Fujita, Y. Tsuji, A. Irie, S. Matsushita and Y. Nishimura. Augmentation of immune response by altered peptide ligands of the antigenic peptide in a human CD4+ T-cell clone reacting to TEL/AML1 fusion protein. Tissue Antigens 54:153-161, 1999
X.P. Zhang, W. Puzon-McLaughlin, A. Irie, N. Kovach, N.L. Prokopishyn, S. Laferte, K. Takeuchi, T. Tsuji and Y. Takada. a3b1 adhesion to laminin-5 and invasin: critical and differential role of integrin residues clustered at the boundary between a3 N-terminal repeats 2 and 3. Biochemistry 38:14424-14431, 1999
入江 厚、他１名 Ｔ細胞とＭＨＣの相互作用 免疫 しくみと疾患のすべて （宮坂信之 編） 羊土社、p30-43, 1998（分担）
A. Irie, T. Kamata and Y. Takada. Multiple loop structures critical for ligand binding of the integrin a4 subunit in the upper face of the b-propeller model. Proc.Natl.Acad.Sci.U.S.A. 94 :7198-7203 1997
A.P. Mould, J.A. Askari, S. Aota, K.M. Yamada, A. Irie, Y. Takada, H.J. Mardon and M.J. Humphries. Defining the topology of integrin a5b1-fibronectin interactions using inhibitory anti-a5 and anti-b1 monoclonal antibodies. Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the a5 subunit. J.Biol.Chem. 272:17283-17292, 1997
Y. Takada, T. Kamata, A. Irie, W. Puzon-McLaughlin and X.P. Zhang. Structural basis of integrin-mediated signal transduction. Matrix Biol.16:143-151, 1997
入江 厚、他２名 インテグリンとリガンドの結合機構 蛋白質核酸酵素 42:1679-1686, 1997
N. Matsuura, W. Puzon-McLaughlin, A. Irie, Y. Morikawa, K. Kakudo and Y. Takada. Induction of experimental bone metastasis in mice by transfection of integrin a4b1 into tumor cells. Am.J. Pathol. 148:55-61, 1996
H. Yamamoto, A. Irie, Y. Fukushima, T. Ohnishi, N. Arita, T. Hayakawa and K. Sekiguchi Abrogation of lung metastasis of human fibrosarcoma cells by ribozyme-mediated suppression of integrin a6 subunit expression. Int.J.Cancer 65:519-524, 1996
T. Kamata, A. Irie, M. Tokuhira & Y. Takada Critical residues of integrin aIIb subunit for binding of aIIbb3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3). J.Biol.Chem. 271:18610-18615, 1996
入江 厚、他２名 インテグリンファミリー 臨床病理102:16-23, 1996
入江 厚、他０名 インテグリンの多様性とリガンド認識機構 組織培養22:530-534, 1996
高田義一、鎌田徹治、入江 厚、他１名 インテグリンの構造と機能 実験医学14:2317-2322, 1996
M. Ogiso, M. Ohta, A. Irie, M. Hoshi and M. Komoto. Characterization of neutral glycosphingolipids in rat lens. Exp.Eye Res. 60:193-198, 1995
A. Irie, T. Kamata, W. Puzon-McLaughlin and Y. Takada. Critical amino acid residues for ligand binding are clustered in a predicted b-turn of the third N-terminal repeat in the integrin a4 and a5 subunits. EMBO J. 14:5550-5556, 1995
M. Ogiso, A. Irie, H. Kubo, M. Komoto, T. Matsuno, Y. Koide and M. Hoshi. Characterization of neutral glycosphingolipids in human cataractous lens. J.Biol.Chem. 268:13242-13247, 1993
入江 厚、他１名 インテグリンファミリー メビオ 10:18-25, 1993
M. Ogiso, A. Irie, H. Kubo, M. Hoshi and M. Komoto. Senile cataract-related accumulation of Lewis(x) glycolipid in human lens. J.Biol.Chem. 267:6467-6470, 1992
H. Kubo, G.J. Jiang, A. Irie, M. Morita, T. Matsubara and M. Hoshi. A novel ceramide trihexoside from the eggs of the sea urchin, Hemicentrotus pulcherrimus. J.Biochem. 111:726-731, 1992
H. Kubo, G.J. Jiang, A. Irie, M. Suzuki, F. Inagaki M. Hoshi. A novel difucosylated neutral glycosphingolipid from the eggs of the sea urchin, Hemicentrotus pulcherrimus: I. Purification and structural determination of the glycolipid. J.Biochem. 112:281-285, 1992
関口清俊、入江 厚、他０名 WI-38 生体の科学 43:432, 1992
A. Irie, H. Kubo and M. Hoshi. Glucosylceramide having a novel tri-unsaturated long-chain base from the spermatozoa of the starfish, Asterias amurensis. J.Biochem. 107:578-586, 1990
H. Kubo, A. Irie, F. Inagaki and M. Hoshi. Gangliosides from the eggs of the sea urchin, Anthocidaris crassispina. J.Biochem. 108:185-192, 1990
A. Irie, H. Kubo, F. Inagaki and M. Hoshi. Ceramide dihexosides from the spermatozoa of the starfish, Asterias amurensis, consist of gentiobiosyl- cellobiosyl-, and lactosylceramide. J.Biochem. 108:531-536, 1990
H. Kubo, A. Irie, F. Inagaki and M. Hoshi. Melibiosylceramide as the sole ceramide dihexoside from the eggs of the sea urchin, Anthocidaris crassispina. J.Biochem. 104:755-760, 1988
