粟井(塚本)博丈

氏名  粟井(塚本) 博丈   (Awai (Tsukamoto) Hirotake)
生年月日  1976年(昭和51年)05月30日
所属  熊本大学大学院生命科学研究部 免疫識別学分野
専門分野  免疫生物学、老年医学
所属学会  日本免疫学会、日本がん免疫学会、日本癌学会、米国免疫学会

受賞および助成金獲得状況
平成14年12月 第32回日本免疫学会 Melcher's Travel Award 受賞
平成19年03月 公益財団法人上原記念生命科学財団 海外留学フェローシップ
平成22年11月 公益財団法人武田科学振興財団 医学系研究奨励
平成23年11月 公益財団法人興和生命科学振興財団 研究助成
平成24年12月 公益財団法人安田記念医学財団 癌研究助成
平成25年07月 第17回日本がん免疫学会 若手研究奨励賞受賞
平成26年05月 日本免疫学会 Tadamitsu Kishimoto International Travel Award 受賞
平成26年11月 公益財団法人武田科学振興財団 医学系研究助成

招待講演
塚本博丈 加齢に伴うCD4陽性T細胞の機能不全と、それに伴う抗腫瘍免疫応答の低下
シンポジウム9「がんの進展制御における老化の役割」(10/8発表) 第47回日本癌学会学術総会(名古屋市)2015年10月8日~10日

発表論文
Sayem M., Tomita Y., Yuno A., Hirayama M., Irie A., Tsukamoto H., Senju S., Yuba E., Yoshikawa T., Kono K., Nakatsura T., and Nishimura Y. Identification of Glypican-3-Derived Long Peptides Activating both CD8+ and CD4+ T-cells; Prolonged Overall Survival in Cancer Patients with Th Cell Response. Oncoimmunology 2015 (In Press)

Tsukamoto H., Senju S., Matsumura K., Swain, S.L., and Nishimura Y. IL-6-mediated environmental conditioning of defective Th1 differentiation dampens anti-tumor immune responses in old age. Nat. Commun., 6: 6702 doi: 10.1038/ncomms7702, 2015.

Motoshima T., Komohara Y., Horlad H., Tsukamoto H., Fujita M., Saito Y., Tanoue K., Kasejima Y., Sugiyama Y., Kawano Y., Nishimura Y., Takeya M., Eto M. CXCL10 and CCL2 mRNA expression in monocytes is inversely correlated with the HLA-DR lower fraction of monocytes in patients with renal cell carcinoma. Oncol Lett 2015 (in Press)

Ikeda T., Hirata S., Takamatsu K., Haruta M., Tsukamoto H., Ito T., Uchino M., Ando Y., Nagafuchi S., Nishimura Y., Senju S. Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells. PLoS One 9: e115198, 2014.

塚本博丈 Myeloid-derived suppressor cells (MDSC) によるTh1細胞の抑制機序 臨床免疫・アレルギー科(科学評論社)61: 428-435, 2014.

Tomita Y., Yuno A., Tsukamoto H., Senju S., Kuroda Y., Hirayama M. Irie A., Yatsuda J., Hamada A., Jono H., Yoshida K., Tsunoda T., Daigo Y., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y. Identification of immunogenic LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes and eliciting CD4+ T-cell immunity in patients with malignant disease. Oncoimmunology 3: e28100, 2014.

Tomita Y., Yuno A., Tsukamoto H., Senju S., Yoshimura S., Osawa R., Kuroda Y., Hirayama M., Hamada A., Jono H., Irie A., Tsunoda T., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y. Identification of CDCA1 long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients. Int. J. Cancer 134, 352–366, 2014.

Yatsuda J., Irie A., Harada K., Michibata Y., Tsukamoto H., Senju S., Tomita Y., Yuno A., Hirayama M., Sayem M. A., Takeda N., Shibuya I., Sogo S., Fujiki F., Sugiyama H., Eto M. and Nishimura Y.; Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens. PLoS One 8: e84908, 2013.

Tsukamoto H., Nishikata R., Senju S., and Nishimura Y. Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression. Cancer Immunol. Res. 1: 64-76, 2013.

塚本博丈、西村泰治 腫瘍免疫の最前線:T細胞を介した抗腫瘍免疫応答 実験医学9月号増刊(羊土社)31:32-39, 2013.

Tomita Y., Yuno A., Tsukamoto H., Senju S., Kuroda Y., Hirayama M., Irie A., Kawahara K., Yatsuda J., Hamada A., Jono H., Yoshida K., Tsunoda T., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y. Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor. Clin. Cancer Res. 15: 4508-4520, 2013.

Horlad H., Fujiwara Y., Takemura K., Ohnishi K., Ikeda T., Tsukamoto H., Mizuta H., Nishimura Y., Takeya M., Komohara Y. Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells. Mol. Nutr. Food Res. 57: 1046-1054, 2013. (Citation Index: 9, Impact Factor: 4.603)

Tsukamoto H., Huston G.E., Dibble J., Duso D.K. and Swain S.L. Bim limits the accumulation of naïve CD4 T cells with age-related defects by regulating their lifespan. J. Immunol. 185: 4535-4544, 2010.

塚本博丈、西村泰治 炎症・免疫分野とノーベル賞 炎症と免疫(先端医学社)18:192-196, 2010.

Tsukamoto H., Clise-Dwyer K., Huston G.E., Duso, D.K., Buck A.L., Haynes L. and Swain S.L. Age-associated increase in lifespan of naïve CD4 T cells contributes to T cell homeostasis but facilitates development of functional defects. Proc. Natl. Acad. Sci. U S A. 106: 18333-18338, 2009.

Tsukamoto H., Irie A., Senju S., Hatzopoulos A.K., Wojnowski L. and Nishimura Y. B-Raf-mediated signaling pathway regulates T cell development. Eur. J. Immunol. 38: 518-527, 2008. (Citation Index: 10, Impact Factor: 4.034)

Irie A., Harada K., Tsukamoto H., Kim J-R., Araki N. and Nishimura Y. Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells. Int. Immunol. 18: 1737-1747, 2006

塚本博丈、西村泰治 抗原認識のメカニズム Medicina(医学書院)43 (6), 2006.

Tsukamoto H., Irie A., Kim J-R., Chen Y-Z., Takeshita K., and Nishimura Y. TCR ligand avidity determines the mode of B-Raf/Raf-1/ERK activation leading to the activation of human CD4+ T cell clone. Eur. J. Immunol. 36: 1926-1937, 2006. (Citation Index: 11, Impact Factor: 4.034)

Kim, J-R., Irie, A., Tsukamoto, H., and Nishimura, Y. A role of kinase inactive ZAP-70 in altered peptide ligand stimulated T cell activation. Biochem. Biophys. Res. Comm. 341: 19-27, 2006.

Hosaka S., Nakatsura T., Tsukamoto H., Hatayama T., Baba H. and Nishimura Y. Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo. Cancer Sci. 97: 623-632, 2006.

塚本博丈、西村泰治 CLIP置換型インバリアント鎖遺伝子を利用したペプチド/MHC-I複合体発現細胞システムの構築 Medical Science Digest(ニューサイエンス社)31 (5): 5-6, 2005.

塚本博丈、西村泰治 MHCによる抗原提示 バイオ研究マスターシリーズ免疫学集中マスター(羊土社)84-92, 2005.

Yoshitake Y., Nakatsura T., Monji M., Senju S., Matsuyoshi H., Tsukamoto H., Hosaka S., Komori H., Fukuma D., Ikuta Y., Katagiri T., Furukawa Y., Ito H., Shinohara M., Nakamura Y. and Nishimura Y. Proliferation potential-related protein, an ideal esophageal cancer antigen for immnotherapy, identified using cDNA microarray analysis. Clinical Cancer Research 10: 6437-6448, 2004. 

Tsukamoto H., Irie A. and Nishimura Y. B-Raf contributes to sustained extracellular signal-regulated kinase activation that regulates IL-2 production through the T cell receptor. J. Biol. Chem. 279: 48457-48465, 2004.

Nishimura Y., Chen Y-Z., Uemura Y., Tanaka Y., Tsukamoto H., kanai T., Yokomizo H., Yun C., Matsuoka T., Irie A. and Matsushita S. Degenerate recognition and response of human CD4+ Th cell clones: implications for basic and applied immunology. Mol. Immunol. 40: 1089-1094, 2004.

A, Irie, Y-Z, Chen, H, Tsukamoto, T, Jotsuka, M, Masuda, and Y, Nishimura. Unique T-cell proliferation associated with PKCμ activation and impaired Zap-70 phosphorylation in recognition of overexpressed HLA-DR/partially agonistic peptide complexes. Eur. J. Immunol. 33: 1497-1507, 2003

Uemura, Y., Senju, S., Maenaka, K., Iwai, L.K., Fujii, S., Tabata, H., Tsukamoto, H., Hirata, S., Chen, Y-Z. and Nishimura, Y. Systematic analysis of the combinatorial nature of epitopes recognized by TCR leads to identification of mimicry epitopes for GAD65 specific TCRs. J. Immunol. 170: 947-960, 2003.

Yamane, T., Kunisada, T., Tsukamoto, H., Yamazaki, H., Niwa H., Takada, S. and Hayashi, S. Wnt signaling regulates hemopoiesis through stromal cells. J. lmmunol. 167: 765-772, 2001.

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